殺粉蝶霉素A Piericidin A
NADH-ubiquinone oxidoreductase inhibitor
Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (*plex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
PRODUCT PROPERTIES
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Alternative Name:
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Piericidin A1, Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D
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RTECS:
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YD4588000
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Source/Host:
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Isolated from Streptomyces sp. MST-AS5364.
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Solubility:
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Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
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Long Term Storage:
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-20°C
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Hazard:
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VERY TOXIC.
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MW:
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415.6
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CAS:
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2738-64-9
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Formula:
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C25H37NO4
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Purity:
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≥95% (HPLC)
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Appearance:
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Pale yellow oil.
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普華仕科技發展有限公司 --Puhuashi Technology Development Co., Ltd
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